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Πλοήγηση ανά Θέμα "drug clearance"

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    • Caffeine metabolism in liver cirrhosis 

      Begas, E.; Asprodini, E. K.; Papakosta, S.; Maglaras, L.; Benakis, A.; Dalekos, G. (2005)
      Caffeine is metabolized primarily by CYP1A2. Several methods have been developed for the in vivo assessment of CYP1A2 activity using caffeine as a probe drug (2). These methods include the determination of caffeine clearance ...

    • Clinical effectiveness, safety profile, and pharmacokinetics of daptomycin in pediatric patients: A systematic review 

      Karageorgos S.A., Miligkos M., Dakoutrou M., Tsioutis C. (2016)
      Infections by Gram-positive pathogens pose a public health risk, especially due to increasing antibiotic resistance. Daptomycin has efficacy against most clinically important Gram-positive bacteria. Although experience ...

    • In vitro and in vivo assessment of vitamin A encapsulation in a liposome–protein delivery system 

      Rovoli M., Pappas I., Lalas S., Gortzi O., Kontopidis G. (2019)
      Vitamin A (VA) is an essential nutrient needed in small amounts by humans and supports a wide range of biological actions. Retinol, the most common and most biologically active form of VA has also been found to inhibit ...

    • Pharmacokinetic disposition of amiodarone when given with an intralipid rescue strategy 

      Avedissian S.N., Pham M., Joshi M.D., Scheetz M.H., Salamatipour A., Panickar J.M., Hlukhenka K., Miglis C., Chalkias A., Xanthos T. (2021)
      While the antiarrhythmic drug amiodarone is commonly used in clinical practice, it has a narrow therapeutic index that can lead to acute overdose. One proposed method to deal with this toxicity is lipid emulsion therapy, ...

    • Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia 

      Xie F., Mantzarlis K., Malliotakis P., Koulouras V., Degroote S., Koulenti D., Blot S., Boussery K., Van Bocxlaer J., Colin P., Zakynthinos E., Georgopoulos D., Papathanasiou A., Arvaniti K., Matamis D., Spring A., Bekos V., Komnos A., Zafeiridis T., Vogelaers D. (2019)
      Objectives: Altered linezolid pharmacokinetics (PK) in obese individuals has been hypothesized in previous studies. However, specific dosing recommendations for this population are still lacking. The main goal of this study ...

    • Physiology of intraluminal administration of carbon dioxide as a contrast medium 

      Patelis N., Doulaptsis M., Kykalos S., Spartalis E., Maskanakis A., Georgopoulos S. (2019)
      Background: Carbon dioxide (CO2) exists in nature around us. In the middle of the 20th century, the intraluminal injection of CO2 demonstrated similar results to those of Digital Subtraction Angiography (DSA) with an ...